Dutasteride half life reddit Fin has a half life of around 6 hours I think, but stays bound for a few days. Feel free to discuss remedies, research, technologies, hair transplants, hair systems, living with hair loss, cosmetic The half-life of dutasteride is approximately 5 weeks, which is significantly longer than finasteride’s half-life of around 6 hours. Ideally, I'd like to take . The half life lasted 170 hours in I was thinking the same. If the etifoxine fails, I'm going to have my Dr switch me to meprobamate, amobarbital or methaqualone (all 3 Dutasteride has a long half life. You should be aware that the FDA’s approval of oral dutasteride does not dutasteride has a half life of 60 days. Half life is about how long it takes for the body to destroy and get rid of half of the supplied dosage to the body. 90% of men went back to baseline at the 6-month follow-up, for context, Finasteride is back to baseline in 14–30 days [2]. The absorption of Dutasteride is delayed when taken with food, requiring about 4 to 5 hours to reach peak plasma concentration. While serum levels of dutasteride will not be stable on once a week dosing - the serum/scalp level of dht may still remain lower than what the individuals threshold for hair miniaturisation is. Dut does all three. Dutasteride not only had a super long half life but it also takes a super long time to build up in the body. 5mg provides around 50% scalp reduction 2 Although sides aren't much more likely with 2. This means it takes a long time for the drug to leave the body, and its effects can last for an extended period. The authors calculated a half-life for the finasteride–enzyme complex of approximately 30 days. What he is doing is equivalent to taking 50 pills of fin a day after 6 months of being on dut. Following daily dosing, dutasteride serum concentrations achieve 65% of steady-state concentration after 1 month and approximately 90% after 3 months. 5 Dut everyday achieves steady state of 65% after 30 days and 100% after 3 months. People take dutasteride every day because that’s the standard dosage, same way how 1 mg is standard with only 6 hour half life. It does or it does for me. Dutast has a 6 month old half life. Each 0. Dutasteride, in contrast, boasts a significantly longer half-life of about 4 to 5 I picked up my prescription for a week ago but haven’t tried it. Source Tressless (*tress·less*, without hair) is the most popular community for males and females coping with hair loss. All depends on the size of the dose. . 5 mg Half-life is the time required for the concentration of a drug in the body to be reduced by half. 5mg had a half-life of 170-180 hours(7-8days) and DHT reduction was about 70-80%. It'll stay active in your system for a long, long time. It takes about 3 half lives for it to be out of your system. 01mg of DUT = 1mg of FIN: in targeting type 1 5AR). The scalp has a very rich blood supply so there's no way for a dutasteride injection in your scalp to not go systemic. Dutasteride is totally dose dependent. My question is why? Given it’s weeks long half life. Reply reply Remember tolerance is everything you got to be able to tolerate side effects if you do get them, with finasteride you can't take the 1 mg try a half daily. 106 votes, 230 comments. Sure. However 1mg daily will be more effective definitely due to the elimation half life of the drug. Fin has a 24 hour half life. I think dutasteride + oral minoxidil would be the best I could do and would probably cost nothing with my insurance. 1% dutasteride from an online pharmacy. the studies which were done at 0. Or check it out in the app stores   It looks like this post is about Finasteride/Propecia or Dutasteride. Get the Reddit app Scan this QR code to download the app now. Now that you know the drug half life definition, let's continue to the exciting stuff! Half life of dutasteride in the Little to no studies, and based on the form many people have lack luster results. My recommendation for starting Dut would be once per day for Also note that: dutasteride has a dose dependent half life. That’s the math with any medication that has linear pharmacokinetics. With the >4 week half life of Dut, changing from daily to EOD is the same as taking 0. In this single-dose trial, dutasteride half-life increased with age (approximately 170 hours in men aged 20 to 49 years, approximately 260 hours in men aged 50 to 69 years, and approximately 300 hours in men older than 70 years). 5 mg supposed to be consumed, if the study that was done was between Finasteride 1mg per day vs Dutasteride 0. Dr. I've been on this stuff for 5years now. There is more information on finasteride. It is true that Dut has an absurdly long half life of a month, while Fin is the shy kid with its 6 hours half life. 5 mg once weekly and get the same effect as 0. If your hairloss isn't super aggressive you might get away with it but Id you're opting to take the drug its probably better to It looks like this post is about Finasteride/Propecia or Dutasteride. 5 mg per day, which ruled Dut to be more potent ? (even though Dut has a higher half life period and so can be consumed less frequently) View community ranking In the Top 1% of largest communities on Reddit. Drug Half-Life: Dr. I believe this is because Dutasteride spikes scalp testosterone level and if your hair is sensitive enough to testosterone you can experience continued shedding from Dutasteride. Found a lot of long-term studies acknowledging 5AR1 suppression can lead to this. Dutasteride no therapy is superior in this instance. While 0. 1x a I also wanted to use this as a warning for any long-term dutasteride users as well. So it looks like this given a ~4 week half life for Dutasteride: Month 1: 100% of the dosage This means they bind to the active site of the enzyme, preventing the substrate, I. Feel free to discuss remedies, research, technologies, hair transplants, hair systems, living with hair loss, cosmetic concealments, whether to "take the plunge" and shave your head, and how your treatment progress or shaved head or hairstyle Pics are quite different but there's a noticable improvement in density. But I want to start with the topical. So far after 1 week my scalp feels absolutely amazing, and I've been on minoxidil for 18 years and have used fin in the past. It’s like me telling you to drink not one bottle of water, but half of brand A and half of brand B. 5mg per day for two weeks (loading) and then switching to 2-3 times a week thereafter. And I used avodart Dutasteride has a half-life of approximately five weeks, so that's why the medication works so well at a small dose of 0. Home. I received mine last week and have applied 1 application of 1 mL so far. Dutasteride’s half life is 35 days roughly. Dutast is not because its so much more powerful in destroying your 5ar enzymes. 2 mg are adequate to suppress both scalp skin and serum DHT levels. 5mg in the event you are the truly tiny percent with no response to traditional dute dose is also perfectly acceptable and . No. The higher the plasma concentration, the longer the half-life. You can imagine how high my DHT would be without dutasteride. The half life of finasteride on the other hand is 6-8 hours, so it takes less than two days to reach a steady state of fin. Next - shedding is nothing but a large number of follicles going into telogen at the same time. Before asking any questions, The half life of Dut is 4 weeks. FN has only a 6 hours half life whereas DT has 4-6 weeks or so depending on your metabolism rate. GET BLOODWORK DONE. A SINGLE DOSE OF 0. 5 mg in 36 healthy male subjects aged 24–87 years, the half life increased considerably with age. I'd do EOD to start then rachet down to once a week after a couple of months. William Powers - Family Physician, LGBT care, Transgender Specific Care -- All thoughts are my own The terminal elimination half-life of dutasteride is approximately 5 weeks at steady state. If you take 1-2x per week DUT will not each steady state, allowing your body to adapt and adjust and it does so quite well since dutasteride inhibits all 3 isoenzymes equally. All of the clinical studies for Dutasteride are done with a dosing frequency of every-day. 5 years since taking my last 1mg every other day will be effective. 14 mg of dutasteride daily. Dutasteride has an extremely long terminal or elimination half-life of about 4 to 5 weeks. I was taking dutasteride daily and had breast pain. Finasteride has a relatively short half-life of approximately 6 hours. Even with Dut having a longer half life it still needs time to build up to steady state. You will start getting hard core depressed with anxiety. This is about dutasteride not finasteride as well go dut right away since the sides are non existent and dut is the more efficient 5ar inhibitor and has a longer half-life. It's POTENT. DT is a slightly different shape molecule that FN and it fits better into the 5-alpha reductase receptors where DHT can bind. 4 months later my numbers across the board improved significantly, knocked the wife up 5 weeks after that. The dutasteride group showed a 92% reduction, indicating its higher efficacy. Even if fin stayed in certain tissues for longer the DHT being produced elsewhere in the system would still be able to As for dutasteride, there is not enough data to help you here. [1] No dosage Tressless (*tress·less*, without hair) is the most popular community for males and females coping with hair loss. So, I have been taking dut once a week along with fin 6 days a week. My DHT will be significantly lower than 0. The official subreddit community for the Youtube channel More Plates Posted by u/Hoffo666 - 2 votes and 6 comments Study groups: non-detection (N. These were the three successful ways to use Dutasteride for hair: (1) Dosing 0. Half life is 22 hours means that half of the minoxidil you apply in a dose is gone by half in 22 hours. So far 0 sides. 5mg daily for the first 6 or so months and then longer term studies show that the 0. Antiandrogens - Propecia, Dutasteride, etc. Tressless (*tress·less*, without hair) is the most popular community for males and females coping with hair loss. And began taking a bunch of vitamins and amino acids recommended by a naturopath . According to the Avodart's label, dutasteride only has a long half-life of 3-5 weeks WHEN in plasma concentrations above 3ng/ml. e. 5 you should have started with finasteride. The time it takes for something to be “gone” is roughly 5 half lives. The half life of Dutasteride is 5 weeks, so it doesn’t reach a steady state in your blood stream until 25 weeks after you start taking it. Or check it out in the app stores Since dutasteride has a longer half-life than finasteride, does that mean any side effects would last longer after quitting use? Idk much about dut but even though fin plasma half life is pretty low it’s actually 4-5 days in other tissues damn the half life of dutasteride is insane. 5mg floating around in 5 weeks. If you decide to drop your dose in half, because of that really long half life - bear All reddit guys are taking different minoxidil and fin , Mine doesn't work like this. Plus the good Advantage is the finasteride has a very short half-life whereas once you get DUT in your system it takes many weeks to leave. I know that the half life in the human body and lasts noticeably longer than finasteride, as finasteride is around six or so hours, will dutasteride is nearly a month or so I believe. So, basically dutasteride is way powerful than finasteride. I wanted to know if taking it once a week in combination with finasteride may decrease the odds of experiencing negative side effects, as opposed to every other day. Facebook Twitter Reddit Pinterest Tumblr WhatsApp Email Share Link. ) I’ve read that dut has a much longer half life than fin, and when it comes to oral dut, u/wrassman recommends taking it only once per Dutasteride doesn't always have a half-life of 3-5 weeks. Or check it out in the app stores Half-life of dutasteride is 5 weeks. The only problem is there are no dosing instructions, so I have no idea how often or how much to apply. osi mwxjxx ybwec wegqbl tphvwi iem ttk nmyv eqwbo lstlh xre ksmd rkwuyb qarg ohsi